Saltar apartados

Líneas de investigación y publicaciones

 

1. Aminoácidos y péptidos en síntesis orgánica

  • Chinchilla, R.; Nájera, C. Asymmetric Synthesis of a-Amino Acids Using Polymer-Supported Cinchona Ammonium Salts as Phase Transfer Catalysts In Asymmetric Synthesis and Applications of a-Amino Acids; Soloshonok, V.; Izawa, K., Eds.; ACS Symposium Series, ACS 2009 ; Chapter 16:pp 251-264.
  • Alonso, F.; Davies, S. G.; Elend A. S.; Leech, M. A.; Roberts, P. M.; Smith, A. D.; Thomson, J. E. Stereoselective functionalisation of cis - and trans -2-ferrocenyl-3-pivaloyl-1,3-oxazolidin-5-ones; asymmetric synthesis of ( R )- and ( S )-2-alkyl-2-aminopent-4-enoic acids and (2 R ,3 S )-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid. Org. Biomol. Chem. 2009 , 7 , 527-536. ( pdf )
  • Alonso, F.; Davies, S. G.; Elend A. S.; Smith, A. D. Kinetic and thermodynamic control in the stereoselective formation of trans - and cis -4-alkyl-2-ferrocenyl-3-pivaloyl-1,3-oxazolidin-5-ones. Org. Biomol. Chem. 2009 , 7 , 518-526. ( pdf )

2. Catalizadores bifuncionales quirales

  • Avila, A.; Chinchilla, R.; Gómez-Bengoa, E.; Nájera, C. Enantioselective Synthesis of Succinimides by Michael Addition of Aldehydes to Maleimides Organocatalyzed by Chiral Primary Amine-Guanidines. Eur. J. Org. Chem.. 2013 , 5085-5092. ( pdf )
  • Avila, A.; Chinchilla, R.; Nájera, C. Enantioselective Michael Addition of α,α-Disubstituted Aldehydes to Maleimides Organocatalyzed by Chiral Primary Amine-Guanidines. Tetrahedron: Asymmetry , 2012 , 23 , 1625-1627. ( pdf )

3. Organocatálisis y nuevos materiales

  • Moles, F. J. N.; Guillena G.; Nájera, Aqueous Enantioselective Aldol Reaction of Methyl- and Phenylglyoxal Organocatalyzed by N-Tosyl-(Sa)-binam-L-prolinamide. Synlett 2015, 26, 656-660. (pdf)
  • Moles, F. J. N.; Guillena G.; Nájera, C. Gómez-Bengoa, E. Glyoxylic Acid versus Ethyl Glyoxylate for the Aqueous Enantio­selective Synthesis of α-Hydroxy-γ-Keto Acids and Esters by the N-Tosyl-(Sa)-binam-l-prolinamide-Organocatalyzed Aldol Reaction. Synthesis 2015, 47, 549-561 (pdf)
  • Trillo, P.; Baeza, A.; Nájera, C.  Bis(2-aminobenzoimidazole)-Organocatalyzed Asymmetric Alkylation of Activated Methylene Compounds with Benzylic and Allylic Alcohols. Synthesis 2014, 46, 3399-3407. (pdf)
  • Moles, F. J. N.; Bañón-Caballero, A.; Guillena G.; Nájera, C. Enantioselective aldol reactions with aqueous 2,2-dimethoxyacetaldehyde organocatalyzed by binam-prolinamides under solvent-free conditions. Tetrahedron: Asymmetry 2014, 25, 1323. (pdf)
  • Moles, F. J. N.; Guillena G.; Nájera, C. Aqueous organocatalyzed aldol reaction ofglyoxylic acid for the enantioselective synthesis of alpha-hydroxy-gamma-keto acids. RSC Advances 2014, 4, 9963.(pdf)
  • Bañón-Caballero, A.; Guillena, G.; Nájera, C. Solvent-free enantioselective organocatalyzed aldol reactions. Mini-Rev. Org. Chem. 2014, 11, 118-128. (DOI)
  • Flores-Ferrándiz, J.; Chinchilla, R. Solvent-Dependent Enantioswitching in the Michael Addition of α,α-Disubstituted Aldehydes to Maleimides Organocatalyzed by Mono-N-Boc-Protected Cyclohexa-1,2-Diamines. Tetrahedron: Asymmetry 2014, 25, 1091-1094. (pdf)
  • Avila, A.; Chinchilla, R.; Fiser, B.; Gómez-Bengoa, E.; Nájera, C. Enantioselective Michel Addition of Isobutyraldehyde to Nitroalkenes Organocatalyzed by Chiral Primary Amine-Guanidines.Tetrahedron: Asymmetry 2014, 25, 462-467.(pdf)
  • Avila, A.; Chinchilla, R.; Gómez-Bengoa, E.; Nájera, C.Enantioselective Michael Addition of Aldehydesto Maleimides Organocatalyzed by Chiral 1,2-Diamines: An Experimental and Theoretical Study. Tetrahedron: Asymmetry 2013, 24, 1531-1535. (pdf)
  • Fernández-Ibáñez, M. A.; Maciá, B.; Alonso, D. A.; Pastor, I. P. Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis. Molecules 2013 , 18 , 10108-10121. (DOI)
  • Gómez-Torres, E.; Alonso, D. A.; Gómez-Bengoa, E.; Nájera, C. Enantioselective Synthesis of Succinimides by Michael Addition of 1,3-Dicarbonyl Compounds to Maleimides Catalyzed by a Chiral Bis(2-aminobenzimidazole) Organocatalyst. Eur. J. Org. Chem. 2013 , 1434-1440. (DOI)
  • Bañón-Caballero, A.; Guillena, G.; Nájera, C. Solvent-free enantioselective Friedländer condensation using wet binam-prolinamides as organocatalysts. J. Org. Chem. 2013 , 78 , 5349–5356 ( pdf )
  • Guillena, G. Organocatalyzed aldol reactions In Modern Methods in Stereoselective Aldol Reactions; Marhwald, R. Ed, Wiley-VCH: Weinheim 2013 , pp 155-268. ( pdf )
  • Guillena, G. Alpha-Heteroatom Functionalization of Carbonyl Compounds In Comprehensive Enantioselective Organocatalysis, Dalko, P.I, Wiley-VCH: Weinheim, 2013 , pp 757-790. ( pdf )
  • Guillena, G.; Ramón, D. J.; Yus, M. Asymmetric organocatalyzed Morita-Baylis-Hillman reactions. In Catalysis ; Spivey, J. J.; Gupta, M., Eds.; Royal Society of Chemistry: Cambridge, 2012 , Vol. 24 , pp 223-252
  • Tarí, S.; Avila, A.; Chinchilla, R.; Nájera, C.Enantioselective Quaternization of 4-Substituted  Oxazol-5-(4 H )-ones Using Recoverable Cinchona -Derived Dimeric Ammonium Salts as Phase-Transfer Organocatalysts. Tetrahedron: Asymmetry , 2012 , 23 , 176-180. ( pdf )
  • Monge, A.; Pleixats, R.; Cattoën, X.; Chi Man, M. W.; Alonso, D. A.; Nájera, C . Recyclable silica-supported prolinamide organocatalysts for direct asymmetric aldol reaction in water. Green Chem. 2012 , 14 , 1601-1610.  DOI: 10.1039/C2GC35227C
  • Guillena, G.; Ramón, D. J.; Yus, M. Asymmetric organocatalyzed Morita-Baylis-Hillman reactions. In Catalysis ; Spivey, J. J.; Gupta, M., Eds.; Royal Society of Chemistry: Cambridge, 2012 , Vol. 24, pp 223-252. (DOI: pdf )
  • Guillena, G.; Nájera, C.; Ramón, D. J. Enantioselective Intermolecular Aldol Additions and Related Morita-Baylis-Hillman Processes. In Enantioselective Organocatalyzed Reactions II ; Mahrwald, R., Ed.; Springer: Heidelberg, 2011 , Vol. II , pp. 245-342.
  • Ramon, D. J.; Guillena, G. Enantioselective alfa-Heterofunctionalization of Carbonyl Compounds .In Enantioselective Organocatalyzed Reactions I ; Mahrwald, R., Ed.; Springer: Heidelberg, 2011 , Vol. I , pp. 107-145
  • Monge, A.; Pleixats, R.; Cattoën, X.; Man, M. W. C.; Alonso, D. A.; Almasi, D.; Nájera, C. Prolinamide bridged silsesquioxane as an efficient and eco-compatible asymmetric organocatalyst . New. J. Chem. 2011 , 35 , 2766-2772. DOI: 10.1039/C1NJ20516A
  • Gómez-Torres, E.; Alonso, D. A.; Gómez-Bengoa, E.; Nájera, C. Conjugate Addition of 1,3-Dicarbonyl Compounds to Maleimides Using a Chiral C 2 -Symmetric Bis(2-aminobenzimidazole) as Recyclable Organocatalyst Org. Lett. 2011, 13 , 6106-6109. DOI: 10.1021/ol202599h
  • Tarí, S.; Chinchilla, R.; Nájera, C; Yus, M.Enantioselective Alkylation of  b-Keto Esters Promoted by Dimeric Cinchona -Derived Dimeric Ammonium Salts as Recoverable Organocatalysts. Arkivoc , 2011 , ( vii ), 116-127. ( pdf )
  • Guillena, G.; Ramón, D. J. Recent Advances on the organocatalyzed enantioslective alfa-heterofunctionalization of carbonyl compounds. Curr. Org. Chem. , 2011 , 15 , 296-327. 
  • Viózquez; S. F.; Guillena, G.; Nájera, C.; Bradshaw, B.; Etxebarria-Jardi, G.; Bonjoch. J.; Bonjoch. J. ( S a , S )- N -[2´-(4-Methylphenylsulfonamido)-1,1´-Binaphthyl-2-yl]Pyrrolidine-2-Carboxamide: An Organocatalyst for the Direct Aldol Reaction. Org. Synth. 2011, 88 , 317-329 ( pdf )
  • G. Guillena, C. Nájera, S. F. Viózquez, M. Yus ( S )-Binam-L-prolinamide as organocatalyst for the enantioselective conjugate addition of α-alkoxyketones to β-nitrostyrene derivatives, ARKIVOC, 2011 , iii, 1551-7012 ( pdf )
  • Tarí, S.; Chinchilla, R.; Nájera, C. Recoverable Cinchona Ammonium Salts as Organocatalysts in the Enantioselective Michael Addition of β-Keto Esters. Tetrahedron: Asymmetry , 2010 , 21 , 2872-2878. ( pdf )
  • Tarí, S.; Chinchilla, R.; Nájera, C. Enantioselective Michael Reaction of b-Keto Esters Organocatalyzed by Recoverable Cinchona -Derived Dimeric Ammonium Salts. Tetrahedron: Asymmetry , 2009 , 20 , 2651-2654. ( pdf )
  • Chinchilla, R.; Nájera, C.; Ortega, F. J.; Tarí, S. Enantioselective Cyanoformylation of Aldehydes Organocatalyzed by Recyclable Cinchonidine Ammonium Salts. Tetrahedron: Asymmetry , 2009 , 20 , 2279-2286. ( pdf )
  • Bradshaw, B.; Etxebarría-Jardí, G.; Bonjoch, J.; Viózquez, S. F.; Guillena, G.; Nájera, C. Efficient Solvent-Free Robinson Annulation Protocols for the Highly Enantioselective Synthesis of the Wieland-Miescher Ketone and Analogues . Adv. Synth. Catal . 2009 , 351 , 2482-2490. ( pdf )

4. Catalizadores soportados en síntesis orgánica

  • Pérez, J. M.; Ramón, D. J. Cobalt-impregnated magnetite as general heterogeneous catalyst for the hydroacylation reaction of azodicarboxylates. Adv. Synth. Catal.2014356, 3039-3047. (pdf)
  • Almansa, R.; Collados, J. F.; Guijarro, D.; Yus, M. Polymer-supported L-prolinol-based catalysts for the enantioselective addition of dialkylzinc reagents to N-(diphenylphosphinyl)imines. Tetrahedron: Asymmetry, 2013, 24, 116-120. (pdf)
  • Bañón-Caballero, A.; Guillena, G.; Nájera, C. Faggi, E.; Sebastián, R. M.; Vallribera, A. Recoverable silica-gel supported binam-prolinamides as organocatalysts for the enantioselective solvent-free intra- and intermolecular aldol reaction, Tetrahedron , 2013 , 69, 1307-1315.( pdf )
  • Cano, R; Yus, M.; Ramón, D. J. Impregnated Platinum on Magnetite as an Efficient, Fast, and Recyclable Catalyst for the Hydrosilylation of Alkynes. ACS Catalysis, 2012 ,   2 , 1070-1078. ( pdf )
  • Cano, R; Yus, M.; Ramón, D. J. Impregnated Copper or Palladium-Copper on Magnetite as Catalysts for the Domino and Stepwise Sonogashira-Cyclization Processes: A Straightforward Synthesis of Benzo[b]furans and Indoles. Tetrahedron , 2012 , 68 , 1393-1400. ( pdf )
  • Pérez, J. M.; Cano, R.; Yus, M.; Ramón, D. J. Straightforward Synthesis of Aromatic Imines from Alcohols and Amines or Nitroarenes Using an Impregnated Copper Catalyst. Eur. J. Org. Chem. , 2012 , 4548-4554. ( pdf )
  • Bañón-Caballero, A.; Guillena, G.; Nájera, C. Cross-linked-Polymer-Supported N-{2`-[(Arylsulfonyl)amino][1,1`-binaphthalen]-2-yl}prolinamide as Organocatalyst for the Direct Aldol Intermolecular Reaction under Solvent-free Conditions . Helv. Chim. Acta, 2012 , 95 1831–1841. ( pdf )
  • Cano, R; Ramón, D. J.; Yus, M. Impregnated palladium on magnetite as catalyst for multicomponent reductive amination reactions and other related reducing processes. Tetrahedron , 2011 , 67 , 8079-8085. ( pdf )
  • Cano, R; Ramón, D. J.; Yus, M. Impregnated palladium on magnetite, a new catalyst for the ligand-free cross-coupling Suzuki-Miyaura reaction. Tetrahedron , 2011 , 67 , 5432-5436. ( pdf )
  • Cano, R.; Ramón, D. J.; Yus, M. Impregnated Copper on Magnetite as Recyclable Catalyst for the Addition of Alkoxy Diboron Reagents to C-C Double Bonds. J. Org. Chem ., 2010 , 75 , 3458-3460. ( pdf )
  • Bañon-Caballero, A.; Guillena, G.; Nájera, C. Solvent-free direct enantioselective aldol reaction using polystyrene-supported N -sulfonyl-( R a )-binam-D-prolinamide as a catalyst. Green Chem. 2010 , 12 , 1599-1606. ( pdf )

 

5. Complejos metálicos en catálisis asimétrica

  • Martínez, R.; Pastor, I. M.; Yus, M. Enantioselective catalytic lithiation using a chiral binaphthyl derivative as electron carrier. Arkivoc 2014, (ii), 71-84 (pdf)
  • Fernández-Mateos, E.; Maciá, B.; Yus, M. Catalytic enantioselective addition of aryl Grignard reagents to ketones. Eur. J. Org. Chem. 2014, 29, 6519-6526. (pdf)
  • Castelló, L. M.; Nájera, C.; Sansano, J. M. Domino 1,3-Dipolar Cycloadditions of N-Alkyl-a-Amino Esters with Paraformaldehyde: A Direct Access to a-Hydroxymethyl a-Amino Acids. Synthesis 2014, 46, 967-971. (pdf)
  • Nájera, C.; Sansano, J. M. Asymmetric 1,3-dipolar cycloadditions of stabilized Azomethine ylides with nitroalkenes. Curr. Topics Med. Chem. 2014, 14, 1271-1282. (pdf)
  • Nájera, C.; Sansano, J. M. Coinage metal complexes as chiral catalysts for 1,3-dipolar cycloadditions. J. Organomet. Chem. 2014, 771, 78-92. (pdf)
  • Fernández-Mateos, E.; Maciá, B.; Yus, M. Catalytic enantioselective addition of alkyl Grignard reagents to aliphatic aldehydes. Adv. Synth. Catal. 2013, 355, 1249-1254. (pdf)
  • Nájera, C.; Sansano, J. M. Proline and pyrrolidine derivatives. New drug candidates for hepatitis C treatment. Actualite Chimique , 2013 , 370 , pp. 28–30.
  • Mancebo-Aracil, J.; Nájera, C.; Sansano, J. M. Microwave-assisted multicomponent diastereoselective 1,3-dipolar cycloaddition of ethyl glyoxylate derived azomethine ylides. Org. Biomol. Chem. 2013 , 11 , 662-675. (pdf)
  • Castelló, L. M.; Nájera, C.; Sansano, J. M.; Larrañaga, O.; de Cózar, A.; Cossío, F. P. Phosphoramidite-Cu(OTf) 2 Complexes as Chiral Catalysts for 1,3-Dipolar cycloaddition of Iminoesters and Nitroalkenes. Org. Lett. 2013 , 15 (12), pp 2902–2905. (pdf)
  • Pablo, O.; Guijarro, D.; Kovács, G.; Lledós, A.; Ujaque, G.; Yus, M. A Versatile Ru Catalyst for the Asymmetric Transfer Hydrogenation of both Aromatic and Aliphatic Sulfinylimines.Chem. Eur. J., 2012, 18, 1969-1983. (pdf)
  • Pablo, O.; Guijarro, D.; Yus, M. Chiral b-Amino Alcohols as Ligands for the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of N-PhosphinylKetimines.Appl. Sci., 2012, 2, 1-12. (pdf)
  • Fernández-Mateos, E.; Maciá, B.; Yus, M. Catalytic asymmetric addition of alkyllithium reagents to aromatic aldehydes. Eur. J. Org. Chem. 2012, 20, 3732-3736. (pdf)
  • Fernández-Mateos, E.; Maciá, B.; Yus, M. Catalytic enantioselective addition of organoaluminum reagents to aldehydes. Tetrahedron: Asymmetry 2012, 23, 789-794. (pdf)
  • Fernández-Mateos, E.; Maciá, B.; Ramón, D. J.; Yus, M. Catalytic Enantioselective Addition of MeMgBr and Other Grignard Reagents to Aldehydes. Eur. J. Org. Chem ., 2011 , 6851-6855. (pdf )
  • Ramón, D. J.; Yus, M. Alkylation of Carbonyl and imino Groups. In Science of Synthesis: Stereoselective Synthesis 2 ; Molander, G. A., Ed.; Georg Thieme Verlag: Stuttgart, 2011 , Vol. 2 , pp. 349-400.

6. Compuestos organometálicos en síntesis orgánica

  • Martínez, R.; Pastor, I. M.; Yus, M. 1,2-Functionalized Imidazoles as Palladium Ligands: An Efficient and Robust Catalytic System for the Fluorine-Free Hiyama Reaction. Eur. J. Org. Chem. 2014, 872-877 (pdf)
  • Martínez, R.; Pastor, I. M.; Yus, M. Biscarboxy-Functionalized Imidazole and Palladium as Highly Active Catalytic System in Protic Solvents: Methanol and Water. Synthesis 2014, 46, 2965-2975 (pdf)
  • Barros, O. S. R.; Sirvent, J. A.; Foubelo, F.; Yus, M. Diastereoselective Allylation and Crotylation of N-tert-Butanesulfinyl Imines with Allylic Alcohols. Chem. Commun. 2014, 50, 6898-6901. (pdf)
  • García-Muñoz, M. J.; Dema, H. K., Foubelo, F.; Yus, M. Base-Promoted Diastereoselective Addition of Nitromethane and Nitroethane to N-tert-Butylsulfinyl Imines: Synthesis of N-protected a-Amino Acids and Amino Ketones. Tetrahedron: Asymmetry 2014, 25, 362-372. (pdf)
  • Foubelo, F.; Yus, M. Diastereoselective Indium-Promoted Allylation of Chiral N-Sulfinyl Imines. Eur. J. Org. Chem. 2014, 485-491. (pdf)
  • Buxaderas, E.; Alonso, D. A.; Nájera, C.  Synthesis of Dihydroisobenzofurans via Palladium-catalyzed Sequential Alkynylation/Annulation of 2-Bromobenzyl and 2-Chlorobenzyl Alcohols under Microwave Irradiation; Adv. Synth. Catal. 2014, 356, 3415-3421. (pdf)
  • Buxaderas, E.; Alonso, D. A.; Nájera, C.  Microwave-assisted Palladium-catalyzed Highly Regio- and Stereoselective Head to Head Dimerization of Terminal Aryl Alkynes in Water; RSC Advances 2014, 4, 46508-46512. (pdf)
  • Chinchilla, R.; Nájera, C. Chemicals from Alkynes with Palladium Catalysts. Chem. Rev.2014, 114, 1783-1826. (pdf)
  • Machura, B.; Gryca, I.; Ma%u0142ecki, J. G.; Alonso, F.; Moglie, Y. p -Tolylimido rhenium(V) complexes. Synthesis, X-ray studies, spectroscopic characterization, DFT calculations and catalytic activity. Dalton Trans. 2014 , 43 , 2596-2610. ( pdf )
  • Yus, M.; González-Gómez, J. C.; Foubelo, F. Diastereoselective Allylation of Carbonyl Compounds and Imines:Application to the Synthesis of Natural Products. Chem. Rev. 2013 , 113 , 5595-5698. ( pdf )
  • Sirvent, J. A.; Foubelo, F.; Yus, M. Chiral Aminated α-Methylenebenzocycloalkenes from o-Bromoaryl Aldehydes and Ketones. Eur. J. Org. Chem. 2013 , 2461-2471. ( pdf )
  • García-Muñoz, M. J.; Zacconi, F.; Foubelo, F.; Yus, M. Indium-Promoted Diastereo- and Regioselective Propargylation of ChiralSulfinylimines. Eur. J. Org. Chem. 2013 , 1287-1295. ( pdf )
  • Bosque, I.; Foubelo, F.; González-Gómez, J. C. A general protocol to afford enantioenriched linearhomoprenylic amines. Org. Biomol. Chem. 2013 , 11 , 7507-7515. ( pdf )
  • Fernández-Ibáñez, M. A.; Maciá, B.; Alonso, D. A.; Pastor, I. P. Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis. Molecules 2013 , 18 , 10108-10121. DOI: 10.3390/molecules180910108
  • Buxaderas, E.; Alonso, D. A.; Nájera, C.   Copper-Free Oxime–Palladacycle-Catalyzed Sonogashira Alkynylation of Deactivated Aryl Bromides and Chlorides in Water under Microwave Irradiation Eur. J. Org. Chem. 2013 , 5864-5870. DOI:10.1002/ejoc.201300785
  • González-Gómez, J. C.; Foubelo, F.; Yus, M. Preparation of Enantioenriched Homoallylic Primary Amines. Org. Synth. 2012 , 89 , 88-97. ( pdf )
  • Cívicos, J. F.; Alonso, D. A.; Nájera, C. Microwave-Promoted Copper-free Sonogashira-Hagihara Couplings of Aryl Imidazolylsulfonates in water. Adv. Synth. Catal. 2013 , 355 , 203-205. DOI: 10.1002/adsc.201200629
  • Sirvent, J. A.; Foubelo, F.; Yus, M. Diastereoselective indium-mediated allylation of N-tert-butanesulfinylketimines: easy access to asymmetric quaternary stereocenters bearingnitrogen atoms. Chem. Commun. 2012 , 48 , 2543-2545. ( pdf )
  • Nador, F.; Moglie, Y.; Ciolino, A.; Pierini, A.; Dorn, V.; Yus, M.; Alonso, F.; Radivoy, G. Direct reductive amination of aldehydes using lithium-arene(cat.) as reducing system. A simple one-pot procedure for the synthesis of secondary amines. Tetrahedron Lett. 2012 , 53 , 3156-3160. ( pdf )
  • Alonso, F.; Yus, M. Heterogeneous catalytic homocoupling of terminal alkynes. ACS Catal. 2012 , 2 , 1441-1451. ( pdf )
  • Cívicos, J. F.; Alonso, D. A.; Nájera, C. Oxime Palladacycle-Catalyzed Suzuki-Miyaura Arylation and Alkenylation of Aryl Imidazolylsulfonates under Aqueous and Phosphane-free Conditions. Eur. J. Org. Chem. 2012 , 3670-3676. DOI: 10.1002/ejoc.201200368
  • Cívicos, J. F.; Alonso, D. A.; Nájera, C. Microwave-Promoted Suzuki-Miyaura Cross-Coupling of Aryl Imidazolylsulfonates in water. Adv. Synth. Catal. 2012 , 354 , 2771-2776.  DOI: 10.1002/adsc.201200364
  • Guijarro, D.; Pastor, I. M.; Yus, M. Non-Deprotonating Methodologies for Organolithium Reagents Starting from Non-Halogenated Materials. Part 2: Transmetallation and Addition to Multiple Bonds. Curr.Org. Chem., 2011, 15, 2362-2389; ChemInform, 2011, 2342, issue 2349. (pdf)
  • Guijarro, D.; Pastor, I. M.; Yus, M. Non-Deprotonating Methodologies for Organolithium Reagents Starting from Non-Halogenated Materials. Part 1: Carbon-Heteroatom Bond Cleavage. Curr. Org. Chem., 2011, 15, 375-400. (pdf)
  • Dema, H. K.; Foubelo, F.; Yus, M. Indium-mediated Allylation of N-tert-Butylsulfinylaldimines with Dimethyl 2-[2-(Chloromethyl)allyl]malonate. Jordan J. Chem. 2011 , 6 , 247-255. ( pdf )
  • Yus, M.; González-Gómez, J. C.; Foubelo, F. Catalytic Enantioselective allylation of Carbonyl Compounds and Imines. Chem. Rev. 2011 , 111 , 7774-7854. ( pdf )
  • Martínez-Asencio, A.; Yus, M.; Ramón, D. J. Palladium(II) acetate as catalyst for the   N-alkylation of aromatic amines, sulfonamides and related nitrogenated compounds with alcohols by a hydrogen autotransfer process. Synthesis , 2011 , 3730-3740. ( pdf )
  • Martínez-Asencio, A.; Ramón, D. J.; Yus, M. N-Alkylation of poor nucleophilic amines and derivatives with alcohols by a hydrogen autotransfer process catalyzed by copper(II) acetate: scope and mechanistic considerations. Tetrahedron , 2011 , 67 , 3140-3149. ( pdf )
  • Chinchilla, R.; Nájera, C.Recent Advances in Sonogashira Reactions. Chem. Soc. Rev. , 2011 , 40 , 5084-5121. ( pdf )
  • Cívicos, J. F.; Alonso, D. A.; Nájera, C. Oxime Palladacycle-Catalyzed Suzuki-Miyaura Alkenylation of Aryl-, Heteroaryl-, Benzyl-, and Allyl Chlorides under Microwave Irradiation Conditions . Adv. Synth. Catal. 2011 , 353 , 1683-1687. DOI: 10.1002/adsc.201100019
  • Cívicos, J. F.; Gholinejad, M.; Alonso, D. A.; Nájera, C. Phosphane-Free Suzuki-Miyaura Coupling of Aryl Imidazolylsulfonates with Arylboronic Acids and Potassium Aryltrifluoroborates under Aqueous Conditions. Chem. Lett. 2011 , 40 , 907-909. DOI: 10.1246/cl.2011
  • González-Gómez, J. C.; Medjahdi, M.; Foubelo, F.; Yus, M. Stereoselective alfa-Aminoallylation of Aldehydes with Chiral tert-Butanesulfinamides and Allyl Bromides. J. Org. Chem. 2010 , 75 , 6308-6311. ( pdf )
  • Martínez-Asencio, A.; Ramón, D. J.; Yus, M. N-Alkylation of poor nucleophilic amine and sulfonamide derivatives with alcohols by a hydrogen autotransfer process catalyzed by copper(II) acetate. Tetrahedron Lett. , 2010 , 51 , 325-327. ( pdf )
  • Alonso, F.; Foubelo, F.; González-Gómez, J. C.; Martínez, R.; Ramón, D. J.; Riente, P.; Yus, M. Efficiency in chemistry: From hydrogen autotransfer to multicomponent catalysis. Mol. Divers. , 2010 , 14 , 411-424. ( pdf )
  • Guillena, G.; Ramón, D. J.; Yus, M. Hydrogen autotransfer in the N-alkylation of amines and related compounds using alcohols and amines as electrophiles. Chem. Rev. , 2010 , 110 , 1611-1641. ( pdf )
  • Alonso, D. A.; Nájera, C. Oxime-derived Palladacycles as Source of Palladium Nanoparticles. Chem. Soc. Rev. 2010 , 39 , 2891-2902. DOI: 10.1039/B821314N
  • Alonso, D. A.; Nájera, C.; Pastor, I.; Yus, M. Transition Metal-Catalyzed Synthesis of Hydroxylated Arenes. Chem. Eur. J. 2010 , 316 , 5274-5284. DOI: 10.1002/chem.201000470
  • González-Gómez, J.C.; Foubelo, F.; Yus, M. Stereocontrolled synthesis of 1,3-amino alcohols by reduction of substituted 2-1-[tert-butylsulfinyl)amino]alkylcyclohexanones. Synthesis 2009 , 2083-2088. ( pdf )
  • González-Gómez, J. C.; Foubelo, F.; Yus, M. Modular Stereocontrolled Assembly of R2Zn, Cyclic Enones and N-tert-Butylsulfinyl Imines. J. Org. Chem. 2009 , 74 , 2547-2553. ( pdf )
  • Ramón, D. J.; Yus, M. 1,3-Dienes: Synthesis by reduction. In Science of Synthesis ; Rawal, V. H.; Kozmin, S. A., Eds.; Georg Thieme Verlag: Stuttgart, 2009 , Vol. 46 , pp. 523-548.

7. Hidrocarburos aromáticos policíclicos. Aplicación en nuevos materiales

  • Chiappe, G.; Louis, E.; Guijarro, A.; San-Fabian, E.; Verges, J. A., Role of potassium orbitals in the metallic behavior of K3picene. Phys. Rev. B: Condens. Matter Mater. Phys. 2014, 90, (12),035109 (pdf )
  • Chiappe, G.; Louis, E.; Guijarro, A.; San-Fabian, E.; Verges, J. A., Exponential decay of spin-spin correlation between distant defect states produced by contour hydrogenation of polycyclic aromatic hydrocarbon molecules. Phys. Rev. B: Condens. Matter Mater. Phys. 2013, 87, (12), (pdf)
  • Verges, J. A.; de Andres, P. L.; San-Fabian, E.; Chiappe, G.; Louis, E.; Guijarro, A., Spin alignment of extra electrons in K-phenanthrene clusters taken from the crystalline tripotassium-intercalated phenanthrene structure. Phys. Rev. B: Condens. Matter Mater. Phys. 2012, 85, (16), 165102/1. (pdf)
  • de laViuda, M.; Yus, M.; Guijarro, A., On the nature of lithium biphenyl in ethereal solvents. A critical analysis unifying DFT calculations, physicochemical data in solution, and a X-ray structure. J PhysChem B 2011,115, (49), 14610. (pdf)
  • San-Fabian, E.; Guijarro, A.; Verges, J. A.; Chiappe, G.; Louis, E., PPP Hamiltonian for polar polycyclic aromatic hydrocarbons.Eur. Phys. J. B, 2011, 81, (2), 253. 
  • de Andres, P. L.; Guijarro, A.; Verges, J. A., Crystal structure and electronic states of tripotassiumpicene. Phys. Rev. B: Condens. Matter Mater. Phys. 2011, 83, (24), 245113/1.(pdf)
  • de Andres, P. L.; Guijarro, A.; Verges, J. A., Ab initio electronic and geometrical structures of tripotassium-intercalated phenanthrene. Phys. Rev. B: Condens. Matter Mater. Phys.2011, 84, (14), 144501/1.(pdf)
  • Melero, C.; Guijarro, A.; Yus, M., Structural characterization and bonding properties of lithium naphthalene radical anion, [Li+(TMEDA)2][C10H8(*-)], and lithium naphthalene dianion [(Li+TMEDA)2C10H8(-)2]. Dalton Trans 2009, (8), 1286. 
  • Melero, C.; Perez, H.; Guijarro, A.; Yus, M., Reductive dearomatization of biphenyl: sequential one-pot regioselective introduction of two different electrophiles. Tetrahedron Lett. 2007, 48, (23), 4105. (pdf)

8. Mecanismos y otros aspectos químico-físicos de las reacciones orgánicas

  • Batanero, B.; Barba, F.; Barba, I.; Elinson, M. Reductive electrochemical formation of 6H-dibenzo[b,d]pyran-6-one and 2-benzopyran-1(1H)-one. Tetrahedron Letters 2014, 55, 82-85. (pdf)
  • Barba, F.; Barba, I.; Batanero, B. First aromatic ring acetamidation by anodic oxidation. Electrochemistry Communications 2014, 48, 115-117. (pdf)
  • Perez, H.; Melero, C.; Guijarro, A.; Yus, M., The reaction of biphenyl radical anion and dianion with alkyl fluorides.From ET to SN2 reaction pathways and synthetic applications.Tetrahedron 2009, 65, (52), 10769. (pdf)
  • Melero, C.; Guijarro, A.; Baumann, V.; Perez-Jimenez, A. J.; Yus, M., Carbolithiation of simple terminal and strained internal alkenes by the naphthalene and the biphenyl dianion: new modes of reactivity of highly reduced organic species in solution. Eur. J. Org. Chem. 2007, (33), 5514. (pdf)
  • Melero, C.; Herrera, R. P.; Guijarro, A.; Yus, M., New modes of reactivity in the threshold of the reduction potential in solution. Alkylation of lithium PAH(polycyclic aromatic hydrocarbon) dianions by primary fluoroalkanes: a reaction pathway complementing the classical Birch reductive alkylation. Chem. Eur. J. 2007, 13, (36), 10096. (pdf)

9. Metodologías no contaminantes en síntesis: "Green Chemistry"

  • Baeza, A.; Nájera, C.  Recent Advances in the Direct Nucleophilic Substitution of Allylic Alcohols through SN1-Type Reactions. Synthesis 2014, 46, 25-35. (pdf)
  • Pérez, J. M.; Cano, R.; Ramón, D. J. Multicomponent azide-alkyne cycloaddition catalyzed by impregnated bimetallic nickel and copper on magnetite. RSC Adv.20144, 23943-23951. (pdf)
  • Alonso, F.; Moglie, Y. Catalyst- and solvent-free three-component synthesis of phosphane sulfides. Curr. Green Chem., 2014, 1, 87-93. (pdf)
  • Cano, R.; Yus, M.; Ramón, D. J. Environmentally friendly and regioselective C3-alkylation of indoles with alcohols through a hydrogen strategy. Tetrahedron Lett. , 2013 , 54 , 3394-3397. ( pdf )
  • Collados, J. F.; Toledano, E.; Guijarro, D.; Yus, M. Microwave-Assisted Solvent-Free Synthesis of Enantiomerically Pure N-(tert-Butylsulfinyl)imines. J. Org. Chem., 2012, 77, 5744-5750. (pdf)
  • Martínez-Asencio, A.; Yus, M.; Ramón, D. J. Copper(II) acetate-catalyzed one-pot conversion of aldehydes into primary amides through a Beckmann-type rearrangement. Tetrahedron , 2012 , 68 , 3948-3951. ( pdf )
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Solvent- and catalyst-free regioselective hydrophosphanation of alkenes. Green Chem. 2012 , 14 , 2699-2702. ( pdf )
  • Viózquez, S. F.; Bañón-Caballero, A.; Guillena, G.; Nájera, C. Gómez-Bengoa, E. Enantioselective Direct Aldol Reaction of α-Keto Esters Catalyzed by ( S a )-Binam-D-prolinamide under quasi Solvent-free; Org. Biomol. Chem., 2012 , 10 , 4029-4035. ( pdf )
  • Cano, R.; Ramón, D. J.; Yus, M. Transition-metal-free O-, S-, and N-arylation of alcohols, thiols, amides, amines, and realted heterocycles. J. Org. Chem. , 2011 , 76 , 654-660. ( pdf )
  • Aliaga, M. J.; Ramón, D. J.; Yus, M. Impregnated copper on magnetite: an efficient and green catalyst for the multicomponent preparation of propargylamines under solvent free conditions. Org. Biomol. Chem. , 2010 , 8 , 43-46. ( pdf )

10. Nanocatálisis en síntesis orgánica

  • Pérez, J. M.; Cano, R.; Ramón, D.J. Osmium impregnated on magnetite as a heterogeneous catalyst for the syn-dihydroxylation of alkenes. Appl. Catal. A: Gen.2014470, 177-182. (pdf)
  • Nador, F.; Volpe, M. A.; Alonso, F.; Radivoy, G. Synthesis of N-aryl imidazoles catalysed by copper nanoparticles on nanosized silica-coated maghemite. Tetrahedron 2014, 70, 6082–6087. (pdf)
  • Planellas, M.; Moglie, Y.; Alonso, F.; Yus, M.; Pleixats, R.; Shafir, A. Heck, Sonogashira and Hiyama reactions catalyzed by tris-imidazolium salt-stabilized palladium nanoparticles. Eur. J. Org. Chem. 2014, 3001–3008. (pdf)
  • Yus, M.; Alonso, F. Nickel Catalysis (Heterogeneous). First Update In e-EROS Encyclopedia of Reagents for Organic Synthesis [Online]; John Wiley & Sons Ltd.: Hoboken (USA), 2014. doi: 10.1002/047084289X.rn011.pub2.
  • Planellas, M.; Guo, W.; Alonso, F.; Yus, M.; Shafir, A.; Pleixats, R.; Parella, T. Hydrosilylation of internal alkynes catalyzed by tris-imidazolium salt stabilized palladium nanoparticles. Adv. Synth. Catal. 2014 , 356 , 179-188. ( pdf )
  • Alonso, F. Nickel nanoparticles in the transfer hydrogenation of functional groups In Metal Nanoparticles for Catalysis: Advances and Applications; Tao, F., Ed.; The Royal Society of Chemistry: Cambridge (UK), 2014; Chapter 5, pp. 83-98.
  • Alonso, F.; Moglie, Y.; Pastor-Pérez, L.; Sepúlveda-Escribano, A. Solvent- and ligand-free diboration of alkynes and alkenes catalyzed by platinum nanoparticles on titania. ChemCatChem 2014, 6, 857–865. (pdf)
  • Pérez, J. M.; Cano, R.; Yus, M. Ramón, D. J. Copper-im pregnated magnetite as a heterogeneous catalyst for the homocoupling of terminal alkynes. Synthesis , 2013 , 45 , 1373-1379. ( pdf )
  • Cano, R.; Yus, M. Ramón, D. J. Catalyzed addition of acid chlorides to alkynes by unmodified nano-poder magnetite: synthesis of chlorovinylketones, furans, and related cyclopentenone derivatives. Tetrahedron , 2013 , 69 , 7056-7065. ( pdf )
  • Chinchilla, R.; Nájera, C.Sonogashira Reactions Using NanocatalystsIn Nanocatalysis. Synthesis and Applications ;Polshettiwar, V.; Asefa, T.; John Wiley & Sons, Inc.; Hoboken, NJ, 2013 ; Chapter. 4; pp. 89-131.
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Alkenes as azido precursors for the one-pot synthesis of 1,2,3-triazoles catalyzed by copper nanoparticles on activated carbon. J. Org. Chem. 2013 , 78 , 5031–5037. ( pdf )
  • Albaladejo, M. J.; Alonso, F.; Yus, M. Synthesis of indolizines and heterocyclic chalcones catalyzed by supported copper nanoparticles. Chem. Eur. J. 2013 , 19 , 5242-5245. ( pdf )
  • Nador, F.; Volpe, M. A.; Alonso, F.; Feldhoff, A.; Kirschning, A.; Radivoy, G. Copper nanoparticles supported on silica coated maghemite as versatile, magnetically recoverable and reusable catalyst for alkyne coupling and cycloaddition reactions. Appl. Catal. A: Gen. 2013 , 455 , 39-45. ( pdf )
  • Abdulkin, P.; Moglie, Y.; Knappett, B. R.; Jefferson, D. A.; Yus, M.; Alonso, F.; Wheatley, A. E. H. New routes to Cu(I)/Cu nanocatalysts for the multicomponent click synthesis of 1,2,3-triazoles. Nanoscale 2013 , 5 , 342-350. ( pdf )
  • Cano, R; Yus, M.; Ramón, D. J. First practical cross-alkylation of primary alcohols with a new and recyclable impregnated iridium on magnetite catalyst. Chem. Commun. , 2012 , 48 , 7628-7630. ( pdf )
  • Albaladejo, M. J.; Alonso, F.; Moglie, Y.; Yus, M. Three-component coupling of aldehydes, amines, and alkynes catalyzed by oxidized copper nanoparticles on titania. Eur. J. Org. Chem. 2012 , 3093-3104. ( pdf )
  • Alonso, F.; Buitrago, R.; Moglie, Y.; Sepúlveda-Escribano, A.; Yus, M. Selective hydrosilylation of 1,3-diynes catalyzed by titania-supported platinum. Organometallics 2012 , 31 , 2336-2342. ( pdf )
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Multicomponent click synthesis of potentially biologically active triazoles catalysed by copper nanoparticles on activated carbon in water. Heterocycles, 2012 , 84 (2), 1033-1044. ( pdf )
  • Cano, R.; Ramón, D. J.; Yus, M. Impregnated ruthenium on magnetite as a recyclable catalyst for the N-alkylation of amines, sulfonamides, sulfinamides, and nitroarenes using alcohols as electrophiles by a hydrogen autotransfer process. J. Org. Chem. , 2011 , 76 , 5547-5557. ( pdf )
  • Cano, R.; Ramón, D. J.; Yus, M. Unmodified nano-powder magnetite or iron(III) oxide catalyze the easy and fast synthesis of 4-substituted-4H-pyrans. Synlett , 2011 , 2017-2020. ( pdf )
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Multicomponent click synthesis of 1,2,3-triazoles from epoxides in water catalyzed by copper nanoparticles on activated carbon. J. Org. Chem. 2011 , 76, 8394-8405. ( pdf )
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Click chemistry from organic halides, diazonium salts and anilines in water catalysed by copper nanoparticles on activated carbon. Org. Biomol. Chem. 2011 , 9 , 6385-6395. ( pdf )
  • Alonso, F.; Riente, P.; Yus, M. Nickel Nanoparticles in Hydrogen Transfer Reactions. Acc. Chem. Res. 2011 , 44 , 379-391. ( pdf )
  • Alonso, F.: Melkonian, T.; Moglie, Y.; Yus, M. Homocoupling of terminal alkynes catalysed by ultrafine copper nanoparticles on titania. Eur. J. Org. Chem. 2011 , 2524-2530. ( pdf )
  • Alonso, F.; Buitrago, R.; Moglie, Y.; Ruiz-Martínez, J.; Sepúlveda-Escribano, A.; M. Yus. Hydrosilylation of alkynes catalysed by platinum on titania. J. Organomet. Chem. 2011 , 696 , 368-372. ( pdf )
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Multicomponent synthesis of 1,2,3-triazoles in water catalysed by copper nanoparticles on activated carbon. Adv. Synth. Catal. 2010 , 352, 3208-3214. ( pdf )
  • Nador, F.; Moglie, Y.; Vitale, C.; Yus, M.; Alonso, F.; Radivoy, G. Reduction of polycyclic aromatic hydrocarbons promoted by cobalto or manganese nanoparticles. Tetrahedron 2010 , 66 , 4318-4325. ( pdf )
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Unsupported copper nanoparticles in the 1,3-dipolar cycloaddition of terminal alkynes and azides. Eur. J. Org. Chem. 2010 , 1875-1884. ( pdf )
  • Alonso, F.; Riente, P.; Sirvent, J. A.; Yus, M. Nickel Nanoparticles in Hydrogen-Transfer Reductions: Characterization and Nature of the Catalyst. Appl. Catal. A: Gen. 2010 , 378 , 42-51. ( pdf )
  • Martínez, R.; Ramón, D. J.; Yus, M. Selective N-monoalkylation of aromatic amines with benzylic alcohols by a hydrogen autotransfer process catalyzed by unmodified magnetite. Org. Biomol. Chem. , 2009 , 7 , 2176-2181. ( pdf )
  • Alonso, F.; Riente, P.; Rodríguez-Reinoso, F.; Ruiz-Martínez, J.; Sepúlveda-Escribano, A.; Yus, M. A highly reusable carbon-supported platinum catalyst for the hydrogen-transfer reduction of ketones. ChemCatChem., 2009 , 1 , 75-77. ( pdf )
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Copper nanoparticles in click chemistry: an alternative catalytic system for the cycloaddition of terminal alkynes and azides Tetrahedron Lett. 2009 , 50 , 2358-2362. ( pdf )
  • Alonso, F.; Riente, P.; Yus, M. Wittig-type olefination of alcohols promoted by nickel nanoparticles: Synthesis of polymethoxylated and polyhydroxylated stilbenes. Eur. J. Org. Chem. 2009 , 6034-6042. ( pdf )
  • Alonso, F.; Riente, P.; Yus, M. Synthesis of resveratrol, DMU-212, and analogues through a novel Wittig-type olefination promoted by nickel nanoparticles. Tetrahedron Lett. 2009 , 50 , 3070-3073. ( pdf )
  • Alonso, F.; Riente, P.; Yus, M. One-pot synthesis of stilbenes from alcohols through a Wittig-type olefination reaction promoted by nickel nanoparticles. Synlett 2009 , 1579-1582. ( pdf )
  • Alonso, F.; Riente, P.; Yus, M. Transfer hydrogenation of olefins catalysed by nickel nanoparticles. Tetrahedron 2009 , 65 , 10637-10643. ( pdf )

11. Polímeros funcionalizados en síntesis orgánica

  • Forrat, V. J.; Ramón, D. J.; Yus, M. Enantioselective addition of organozinc reagents to ketones catalyzed by grafted isoborneolsulfonamide polymers and titanium isopropóxido. Tetrahedron: Asymmetry , 2009 , 20 , 65-67. ( pdf )

12. Procesos industriales en química fina: productos farmacéuticos

  • Bradshaw, B.; Etxebarria-Jardi, G.; Bonjoch. J.; Bonjoch. J.; Viózquez; S. F.; Guillena, G.; Nájera, C. Synthesis of ( S )-8a-Methyl-3,4,8,8a- tetrahydro-1,6- (2 H ,7 H )-naphthalenedione via N -tosyl-( S a )-BINAM- L -prolinamide organocatalisis. Org. Synth. 2011, 88 , 330-340. pdf 

13. Química computacional en síntesis orgánica

  • Bosque, I.; Gonzalez-Gomez, J. C.; Guijarro, A.; Foubelo, F.; Yus, M., Concise Total Synthesis and Stereochemical Analysis of Tetraponerines T3 and T4.J. Org. Chem. 2012, 77, (22), 10340. (pdf)
  • Guijarro, A.; de la Viuda, M.; Torregrosa, R.; Penafiel, I.; Pastor, I. M.; Yus, M.; Najera, C., Isoprene-mediatedlithiation of imidazolederivatives: mechanisticconsiderations. ARKIVOC (Gainesville, FL, U. S.), 2010, (5), 12. (pdf)

14. Química heterocíclica

  • Behloul, C.; Bouchelouche, K.; Guijarro, D.; Nájera, C.; Yus, M. Detritylation of Protected Tetrazoles by Naphthalene-Catalyzed Lithiation.Synthesis, 2014, 46, 2065-2070. (pdf)
  • Sirvent, J. A.; Foubelo, F.; Yus, M. Stereoselective Synthesis of Indoline, Tetrahydroquinoline, and Tetrahydrobenzazepine Derivatives from o-Bromophenyl N-tert-Butylsulfinyl Aldimines. J. Org. Chem. 2014, 79, 1356-1367. (pdf)
  • Alonso, F.; Moglie, Y.; Radivoy, G.; Yus, M. Copper-catalysed multicomponent click synthesis of 5-alkynyl 1,2,3-triazoles under ambient conditions. Synlett 2012 , 23 , 2179-2182. ( pdf )
  • Dema, H. K.; Foubelo, F.; Yus, M. Diastereoselective Coupling of N-(tert-Butyl)sulfinyl Imines and Dimethyl Malonate. Synthesis of Enantiomerically Enriched beta-Amino Esters and beta-Lactams. Helv. Chim. Acta 2012 , 95 , 1790-1798. ( pdf )
  • Dema, H.K.; Foubelo, F.; Yus, M. Enantioselective synthesis of α-methylene-γ-butyrolactams using n-tert-butanesulfinamides. Heterocycles 2011 , 82 , 1411-1421. ( pdf )
  • Dema, H. K.; Foubelo, F.; Yus, M. Stereoselective Synthesis of alfa-Methylene-gamma-Butyrolactams from Ethyl 2-(Bromomethyl)acrylate andChiral Sulfinyl Aldimines Mediated by Indium. Heterocycles 2010 , 80 , 125-131. ( pdf )
  • García, D.; Foubelo, F.; Yus, M. Reductive Ring-Opening of Phthalan and Isochroman: Application to the Stereoselective Synthesis of Tetrahydroisoquinolines andTetrahydrobenzazepines. Eur. J. Org. Chem. 2010 , 2893-2903. ( pdf )
  • Foubelo, F.; García, D.; Moreno, B.; Yus, M. Connecting heterocycles via a catalyzed lithiation. Arkivoc 2009 , ix , 183-194. ( pdf )
  • García, D.; Moreno, B.; Soler, T.; Foubelo, F.; Yus, M. Stereoselective synthesis of 3-substituted tetrahydroisoquinolines from phthalan and chiral N-sulfinylimines. Tetrahedron Lett. 2009 , 50 , 4710-4713. ( pdf )
  • Medjahdi, M.; González-Gómez, J. C.; Foubelo, F.; Yus, M. Stereoselective synthesis of azetidines and pyrrolidines from N-tert-butylsulfonyl-(2-aminoalkyl)oxiranes. J. Org. Chem. 2009 , 74 , 7859-7865. ( pdf )
  • García D.; Foubelo, F.; Yus, M. Selective lithiation of 4- and 5-halophthalans. Heterocycles 2009 , 77 , 991-1005. ( pdf )

15. Síntesis asimétrica de alcaloides y de otros compuestos nitrogenados bioactivos

  • Bosque, I.; Bagdatli, E.; Foubelo, F.; González-Gómez, J.C. Regio- and stereoselective aminopentadienylation of carbonyl compounds. J. Org. Chem., 2014, 79, 1796-1804. (pdf)
  • Bosque, I.; González-Gómez, J.C.; Loza, M.I.; Brea, J. Natural tetraponerines: a general synthesis and antiproliferative activity. J. Org. Chem., 2014, 79, 3982-3991. (pdf)
  • Antón-Torrecillas, C.; González-Gómez, J.C. Short asymmetric synthesis of phenanthroindolizines through chiral homoallylic sulfinamines. Org. Biomol. Chem., 2014, 12, 7018-7025. (pdf)
  • Pablo, O.; Guijarro, D.; Yus, M. Microwave-Enhanced Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)imines. Eur. J. Org. Chem., 2014, 7034-7038. (pdf)
  • Sirvent, J. A.; Foubelo, F.; Yus, M. Enantioselective Synthesis of Tetrahydroquinoline Alkaloids (-)-Angustureine and (-)-Cuspareine from Chrial tert-Butanesulfinyl imines. Heterocycles 2014, 88, 1163-1174. (pdf)
  • Guijarro, D.; Pablo, O.; Yus, M. Synthesis of Highly Enantiomerically Enriched Amines by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)Imines. Org. Synth., 2013, 90, 338-349. (pdf)
  • Pablo, O.; Guijarro, D.; Yus, M. Synthesis of NitrogenatedHeterocycles by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)haloimines. J. Org. Chem., 2013, 78, 9181-9189. (pdf)
  • Bosque, I.; González-Gómez, J. C.; Foubelo, F.; Yus, M. Straightforward Access to Enantioenriched 2-Allylpiperidine:Application to the Synthesis of Alkaloids. J. Org. Chem. 2012 , 77 , 780-784. ( pdf )
  • Bosque, I.; González-Gómez, J. C.; Guijarro, A.; Foubelo, F.; Yus, M. Concise Total Synthesis and Stereochemical Analysis of Tetraponerines T3 and T4. J. Org. Chem. 2012 , 77 , 10340-10346. ( pdf )
  • Medjahdi, M.; González-Gómez, J. C.; Foubelo, F.; Yus, M. Enantioselective synthesis of cis- and trans-2-methyl-6-nonylpiperidines: alkaloids solenopsin and isosolenopsin. Heterocycles 2012 , 86 , 727-734. ( pdf )
  • Guijarro, D.; Pablo, O.; Yus, M. Achiral b-amino alcohols as efficient ligands for the ruthenium-catalysed asymmetric transfer hydrogenation of sulfinylimines.Tetrahedron Lett., 2011, 52, 789-791. (pdf)
  • Medjahdi, M.; González-Gómez, J. C.; Foubelo, F.; Yus, M. Concise Route of (-)- and (+)-Aphanorphine. Eur. J. Org. Chem. 2011 , 2230-2234. ( pdf )
  • Guijarro, D.; Pablo, O.; Yus, M. Asymmetric Synthesis of Chiral Primary Amines by Transfer Hydrogenation of N-(tert-Butanesulfinyl)ketimines. J. Org. Chem., 2010, 75, 5265-5270. (pdf)
  • Almansa, R.; Collados, J. F.; Guijarro, D.; Yus, M. Asymmetric synthesis of a- and b-amino acids by diastereoselective addition of triorganozincates to N-(tert-butanesulfinyl)imines. Tetrahedron: Asymmetry, 2010, 21, 1421-1431. (pdf)

16. Síntesis total de productos naturales y análogos

  • González-López, S.; Yus, M.; Ramón, D. J. Enantioselective synthesis of (+)-gossonorol and related systems using organozinc reagents. Tetrahedron: Asymmetry , 2012 , 23 , 611-615. ( pdf )
  • Alonso, F.; Rodríguez-Fernández, M.; Sánchez, D.; Yus, M. Synthesis of perhydrofuro[2,3- b ]furans from isopentenyl alcohol through carbonyl-ene and Wacker-type reactions. Eur. J. Org. Chem. 2011 , 6459-6469. ( pdf )
  • Alonso, F.; Rodríguez-Fernández, M.; Sánchez, D.; Yus, M. Ultrasound-promoted formation of isopentenyl alcohol dianion. Straightforward synthesis of perhydrofuro[2,3- b ]furans. Synthesis 2010 , 3013-3020. ( pdf )
  • Alonso, F.; Sánchez, D.; Soler, T.; Yus, M. Straightforward synthesis of perhydrofuro[2,3- b ]furans through a Wacker-type reaction. Adv. Synth. Catal. 2008 , 350 , 2118-2126. ( pdf )

 

Departamento de Química Orgánica


Universidad de Alicante
Facultad de Ciencias, Fase I
Carretera de San Vicente del Raspeig S/N
03690 San Vicente del Raspeig
Alicante (Spain)

Tel: (+34) 96 590 3549

Fax: (+34) 96 590 3549

Para más información: informacio@ua.es, y para temas relacionados con este servidor Web: webmaster@ua.es

Carretera San Vicente del Raspeig s/n - 03690 San Vicente del Raspeig - Alicante - Tel. 96 590 3400 - Fax 96 590 3464