Lewis acids and organocatalysts towards cooperative asymmetric catalysis
Title: "Lewis acids and organocatalysts towards cooperative asymmetric Catalysis"
Main researcher 1: Carmen Nájera Domingo
Main researcher 2: José Miguel Gil Sansano
Type: R & D Project
Start date: 01/01/2014
End date: 31/12/2016 (extended until 31/12/2017)
Total awarded: 191.180,00 €
Funding organization: Spanish Ministry of Economy and Competitiveness with funds from the General State Budget (PGE)
The asymmetric catalysis constitutes one of the most productive areain organic chemistry with a great impact in different fields such as medicine, pharmacy and biology. In this project either Lewis acids, from privileged chiral ligands and low contaminant metals, or organocatalysts would be used as chiral catalysts.
Chiral Lewis acids would be employed in enantioselective 1,3-dipolar cycloadditions and in direct enantioselective nucleophilic substitution of alcohols.
Chiral organocatalysts would be used in aldol reactions and conjugate additions as well as in direct enantioselective nucleophilic substitution of alcohols.
Cooperative asymmetric catalysis would be carried out by combining a chiral Lewis acid with an achiral organocatalysts and vice versa. These types of cooperative processes would be studied in 1,3-dipolar cycloadditions, conjugate additions and in direct enantioselective nucleophilic substitution of alcohols.
Department of Organic Chemistry
Universidad de Alicante Facultad de Ciencias, Fase I Carretera de San Vicente del Raspeig S/N 03690 San Vicente del Raspeig Alicante (Spain)