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CHIRAL IMINES IN ORGANIC CHEMISTRY: APPLICATION TO THE SYNTHESIS OF ALKALOIDS

 

Title: "Chiral imines in organic chemistry: Application to the synthesis of alkaloids"

Reference: CTQ2017-85093-P

Main researcher: Francisco Foubelo García              

Type: R & D Project (EXCELENCE)

Start date: 01/01/2018

End date: 31/12/2019

Total granted: 65.340,00 €

ERDF total available: 65.340,00 €

Sponsor Agency: Spanish Ministry of Economy, Industry and Competitiveness with ERDF funds and funds from the State Research Agency (AEI).

The present project aims to develop new synthesis methodologies that allow the generation of carbon-carbon and carbon-heteroatom bonds in an effective manner, converting simple molecules (usually easily accessible at a reasonable price) into more complex ones. If in turn stereogenics centers are generated and these are formed in a stereoselective manner, the interest is even much higher. The developed methodologies must be respectful with the environment (green chemistry, minimize the use of solvents and toxic substances) and efficient in terms of mass balances (atom economy, generating the minimum waste) and synthetic operations (step economy) .

1. Study of new synthetic methodologies involving nucleophilic additions to N-tert-butanesulfinyl imines and elimination of the tert-butanesulfinyl group
2. Synthesis of chiral sulfinamides supported on a polymeric matrix
3. Study of the opening of epoxides with nitrogen containing nucleophiles
4. Use of β-keto acids as equivalents of enolates in carbon-carbon bond forming reactions
5. Synthesis of natural products and compounds with complex molecular structures starting from chiral N-tert-butanesulfinamides

Department of Organic Chemistry


Universidad de Alicante
Facultad de Ciencias, Fase I
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03690 San Vicente del Raspeig
Alicante (Spain)

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